Sean G. Yates, MD, Abe DeAnda, MD Same Same but Different: Viscoelastic Hemostatic Assays in Cardiac Surgery. August 26, 2021
View the Article

Faraoni D, DiNardo JA. Viscoelastic hemostatic assays: update on technology and clinical applications. Am J Hematol. 2021 Jul 1. doi: 10.1002/ajh.26285. Online ahead of print.

Allen TW, Winegar D, Viola F. The Quantra system and SEER sonorheometry. In Moore HB, et al. (eds.), Trauma induced coagulopathy. Springer Nature Switzerland AG 2021, pages 693-704.

Bolliger D, Kamber F, Mauermann E. Same but different: viscoelastic hemostatic assays in cardiac surgery.
J Cardiothorac Vasc Anesth. 2021;35:1037-1039.

Allen T.W., Winegar D., Viola F. (2021) The Quantra® System and SEER Sonorheometry. In: Moore H.B., Neal M.D., Moore E.E. (eds) Trauma Induced Coagulopathy. Springer, Cham.
View the Article

Leadbetter N, Givens T, Viola F. Unique Approach to Quality Assurance in Viscoelastic Testing. Journal of Applied Laboratory Medicine (JALM), May 20, 2020. Open Access.
View the Article

Carll T, Wool GD. Basic principles of viscoelastic testing. Transfusion. 2020;60 Suppl 6:S1-S9.

Leadbetter NH, Givens TB, Viola F. Unique approach to quality assurance in viscoelastic testing. J Appl Lab Med. 2020;5:1228-1241.

Bolliger D, Kenichi A Tanaka KA. Platelet count and function-Can we kill two birds with an ultrasound wave?
J Cardiothorac Vasc Anesth. 2019;33:1599-1600.

Allen TW, Viola F. A novel point-of-care approach for improving acute bleeding management. Medical Laboratory Observer. 2018 Sept;50(9);30-34.
View the Article

Sniecinski RM, Tanaka KA. SEER Sonorheometry: listening to what the clot has to say. Anesth Analg. 2016;123:1346-1347.

Ferrante EA, Blasier KR, Givens TB, Lloyd CA, Fischer TJ, Viola F. A novel device for the evaluation of hemostatic function in critical care settings. Anesth Analg. 2016; 123:1372-9.
View the Article

Groves DS, Winegar DA, Fernandez LG, Huffmyer JL, Viola F. Comparison of Coagulation Parameters in Arterial and Venous Blood in Cardiac Surgery Measured Using the Quantra System. J Cardiothoracic Vascular Anesthesia. In press.
View the Article

DeAnda A, Levy G, Kinsky M, Sanjoto P, Garcia M, Avandsalehi KR, Diaz G, Yates SG. Comparison of the Quantra® QPlus® system to thromboelastography in cardiac surgery. J Cardiothorac Vasc Anesth. 2020 Dec 8.
View the Article

Zghaibe W, Scheuermann S, Munting K, Blaudszun G, Besser M, Ortmann E, Klein AA. Clinical utility of the Quantra® point-of-care haemostasis analyser during urgent cardiac surgery Anaesthesia 2020 Mar;75(3):366-373
View the Article

Groves DS, Welsby IJ, Naik BI, Tanaka K, Hauck JN, Greenberg CS, Winegar DA, Viola F. Multicenter Evaluation of the Quantra QPlus System in Adult Patients Undergoing Major Surgical Procedures. Anesthesia & Analgesia, Feb 6, 2020. Open Access.
View the Article

Huffmyer JL, Fernandez LG, Haghighian C, Terkawi AS, Groves DS. Comparison of SEER Sonorheometry with rotational thromboelastometry and laboratory parameters in cardiac Surgery. Anesth Analg. 2016; 123:1390-9.
View the Article

Naik BI, Durieux ME, Knisely A, Sharma J, Bui-Huynh VC, Yalamuru B, Terkawi AS, Nemergut EC. SEER Sonorheometry versus rotational thromboelastometry in large volume blood loss spine surgery. Anesth Analg. 2016,123:1380-9.
View the Article

Reynolds PS, Middleton P, McCarthy H, Spiess B. A comparison of a new ultrasound-based whole blood viscoelastic test (SEER Sonorheometry) versus thromboelastography in cardiac surgery. Anesth Analg. 2016; 123:1400-7.
View the Article

Baryshnikova E, Di Dedda U, Ranucci M. A comparative study of SEER Sonorheometry versus standard coagulation tests, Rotational Thromboelastometry, and Multiple Electrode Aggregometry in cardiac surgery. J Cardiothoracic Vascular Anesthesia.
View the Article

Ekaterina Baryshnikova, PhD, Umberto Di Dedda, MD, and Marco Ranucci, MD, FESC. Are Viscoelastic Tests Clinically Useful to Identify Platelet-Dependent Bleeding in High-Risk Cardiac Surgery Patients?
View PDF

Idowu O, Ifeanyi-Pillette I, Owusu-Agyemang P, Holmes A, Kwater P, Jackson T, Mena G, Lasala J, Heir JS. The quantra hemostasis analyzer compared to thromboelastography (TEG) in the surgical oncologic population: A prospective observational trial. J Surg Oncol. 2021 Jun 17. doi: 10.1002/jso.26578. Online ahead of print.

DeAnda A, Levy G, Kinsky M, Sanjoto P, Garcia M, Avandsalehi KR, Diaz G, Yates SG. Comparison of the Quantra® QPlus® system to thromboelastography in cardiac surgery. J Cardiothorac Vasc Anesth. 2021;35:1030-1036.

Naik BI, Tanaka K, Sudhagoni RG, Viola F. Prediction of hypofibrinogenemia and thrombocytopenia at the point of care with the Quantra QPlus System. Thromb Res. 2021;197:88-93.

Masi P, Hékimian G, Lejeune M, Chommeloux J, Desnos C, Pineton De Chambrun M, Martin-Toutain I, Nieszkowska A, Lebreton G, Bréchot N, Schmidt M, Luyt CE, Combes A, Frere C. Systemic inflammatory response syndrome is a major contributor to COVID-19-associated coagulopathy: insights from a prospective single-center cohort study. Circulation. 2020 Jun 17.
View the Article

Zghaibe W, Scheuermann S, Munting K, Blaudszun G, Besser M, Ortmann E, Klein AA. Clinical utility of the Quantra® point-of-care haemostasis analyser during urgent cardiac surgery Anaesthesia 2020 Mar;75(3):366-373
View the Article

Groves DS, Welsby IJ, Naik BI, Tanaka K, Hauck JN, Greenberg CS, Winegar DA, Viola F. Multicenter Evaluation of the Quantra QPlus System in Adult Patients Undergoing Major Surgical Procedures. Anesthesia & Analgesia, Feb 6, 2020. Open Access.
View the Article

Groves DS, Welsby IJ, Naik BI, Tanaka K, Hauck JN, Greenberg CS, Winegar DA, Viola F. Multicenter evaluation of the Quantra QPlus system in adult patients undergoing major surgical procedures. Anesth Analg. 2020;130:899-909.

Zghaibe W, Scheuermann S, Munting K, Blaudszun G, Besser M, Ortmann E, Klein AA. Clinical utility of the Quantra point‐of‐care haemostasis analyser during urgent cardiac surgery. Anaesthesia. 2020;75:366-373.

Michel S, Piekarski F, Fischer JH, Hettler V, Adam EH, Holzer L, Lotz G, Walther T, Zacharowski K, Raimann FJ. Hemostasis analyzer-supported hemotherapy algorithm in cardiac surgery: protocol for a randomized controlled monocentric trial. JMIR Res Protoc. 2020;9:e17206.

Michelson EA, Cripps MW, Ray B, Winegar DA, Viola F. Initial clinical experience with the Quantra QStat System in adult trauma patients. Trauma Surg Acute Care Open 2020;5:e000581.
View the Article

Ranucci M, Ballotta A, Di Dedda U, Baryshnikova E, Dei Poli M, Resta M, Falco M, Albano G, Menicanti L. The procoagulant pattern of patients with COVID-19 acute respiratory distress syndrome. J Thromb Haemost 2020;18:1747-1741.
View the Article

Groves DS, Winegar DA, Fernandez LG, Huffmyer JL, Viola F. Comparison of coagulation parameters in arterial and venous blood in cardiac surgery measured using the Quantra system. J Cardiothorac Vasc Anesth. 2019;33:976-984.

Baryshnikova E, Di Dedda U, Ranucci M. A comparative study of SEER sonorheometry versus standard coagulation tests, rotational thromboelastometry, and multiple electrode aggregometry in cardiac surgery. J Cardiothorac Vasc Anesth. 2019;33:1590-1598.

Huffmyer JL, Fernandez LG, Haghighian C, Terkawi AS, Groves DS. Comparison of SEER sonorheometry with rotational thromboelastometry and laboratory parameters in cardiac surgery. Anesth Analg. 2016; 123:1390-1399.

Reynolds PS, Middleton P, McCarthy H, Spiess B. A comparison of a new ultrasound-based whole blood viscoelastic test (SEER sonorheometry) versus thromboelastography (TEG) in cardiac surgery. Anesth Analg. 2016; 123:1400-1407.

Naik BI, Durieux ME, Knisely A, Sharma J, Bui-Huynh VC, Yalamuru B, Terkawi AS, Nemergut EC. SEER sonorheometry versus rotational thromboelastometry in large volume blood loss spine surgery. Anesth Analg. 2016; 123:1380-1389.

Naik BI, Durieux ME, Knisely A, Sharma J, Bui-Huynh VC, Yalamuru B, Terkawi AS, Nemergut EC. SEER Sonorheometry versus rotational thromboelastometry in large volume blood loss spine surgery. Anesth Analg. 2016,123:1380-9.
View the Article

Reynolds PS, Middleton P, McCarthy H, Spiess B. A comparison of a new ultrasound-based whole blood viscoelastic test (SEER Sonorheometry) versus thromboelastography in cardiac surgery. Anesth Analg. 2016; 123:1400-7.
View the Article

Baryshnikova E, Di Dedda U, Ranucci M. A comparative study of SEER Sonorheometry versus standard coagulation tests, Rotational Thromboelastometry, and Multiple Electrode Aggregometry in cardiac surgery. J Cardiothoracic Vascular Anesthesia.
View the Article

Ranucci M, Ballotta A, Di Dedda U, Bayshnikova E, Dei Poli M, Resta M, Falco M, Albano G, Menicanti L. The procoagulant pattern of patients with COVID-19 acute respiratory distress syndrome. J Thromb Haemost. 2020;18:1747-1741.
View the Article

Masi P, Hékimian G, Lejeune M, Chommeloux J, Desnos C, Pineton De Chambrun M, Martin-Toutain I, Nieszkowska A, Lebreton G, Bréchot N, Schmidt M, Luyt CE, Combes A, Frere C. Systemic inflammatory response syndrome is a major contributor to COVID-19-associated coagulopathy: insights from a prospective single-center cohort study. Circulation. 2020;142:611-614.
View the Article

Viola F, Lin-Schmidt X, Bhamidipati C, Haverstick DM, Walker WF, Ailawadi G, Lawrence MB. Sonorheometry assessment of platelet function in cardiopulmonary bypass patients: correlation of blood clot stiffness with platelet integrin activity, aspirin usage, and transfusion risk. Thromb Res. 2016; 138:96-102.

Viola F, Lin-Schmidt X, Bhamidipati C, et al. Sonorheometry assessment of platelet function in cardiopulmonary bypass patients: Correlation of blood clot stiffness with platelet integrin  activity, aspirin usage, and transfusion risk. Thrombosis Research. 2016;138:96-102.
View the Article

Corey FS, Walker WF. Sonic estimation of elasticity via resonance: A new method of assessing hemostasis. Ann Biomed Eng. 2015; 44:1405-24.
View the Article

Mauldin FW, Viola F, Hamer TC, Ahmed EM, Crawford SB, Haverstick DM, Lawrence MB, Walker WF. Adaptive force sonorheometry for assessment of whole blood coagulation. Clin Chim Acta. 2010; 411:638-644.
View the Article

Viola F, Mauldin FW, Lin-Schmidt X, Haverstick DM, Lawrence MB, Walker WF. A novel ultrasound-based method to evaluate hemostatic function of whole blood. Clin Chim Acta. 2010; 411:106-113.

Mauldin WF, Viola F, Walker WF. Complex principal components for robust motion estimation. IEEE Trans Ultrason Ferroelec Freq Control. 2010;57:2437-2449.

Viola F, Mauldin FW, Lin-Schmit X, et.al. A novel ultrasound-based method to evaluate hemostatic function of whole blood. Clinica Chimica Acta. 2010;411:106-113.
View the Article

Mauldin WF, Viola F, Walker WF. Complex principal components for robust motion
estimation. IEEE Trans Ultrason Ferroelec Freq Control. 2010;57(11):2437-2449.
View the Article

Viola F, Kramer MD, Lawrence MB, Oberhauser JP, Walker WF. Sonorheometry: a noncontact method for the dynamic assessment of thrombosis. Ann Biomed Eng. 2004;32:696-705.

Viola F, Kramer MD, Lawrence MB, et al. Sonorheometry: a noncontact method for the dynamic assessment of thrombosis. Ann Biomed Eng. 2004;32(5):696-705.
View the Article

Wohlgemut JM, Rossetto A, Davenport R. Compariosn of alternative hemostatic assays – rotational thromboelastometry versus sonorheometry for rapid diagnosis in trauma patients: an interim analysis. International Society on Thrombosis and Haemostasis (ISTH) 2021 Virtual Congress, July 17-21, 2021; Res Pract Thromb Haemost. 2021; 5 (Suppl 1). OC45.2.

Abbes A, Frere C, Loeb J, Djavidi N, Lebreton G, Bougle A. A comparative study of SEER sonorheometry versus thromboelastography during cardiac surgery with cardiopulmonary bypass. International Society on Thrombosis and Haemostasis (ISTH) 2021 Virtual Congress, July 17-21, 2021; Res Pract Thromb Haemost. 2021; 5 (Suppl 1). PB0080.

Washburn Jr TB, Houdijk W, Sudhagoni R. Preoperative measurement of platelet contribution to clot stiffness (PCS) with the Quantra^® QPlus system and bleeding after cardiac surgery. International Society on Thrombosis and Haemostasis (ISTH) 2021 Virtual Congress, July 17-21, 2021; Res Pract Thromb Haemost. 2021; 5 (Suppl 1). LPB0107.

López Jaime FJ, Martín-Téllez S, Doblas-Márquez A, Márquez-Gómez I, Alemany J, Pérez-Raya M, Mena-Santano AM, Muñoz-López DF, Muñoz-Pérez MI, Fernández-Bello I, Montaño A. Hypercoagulability detected by SEER sonorheometry in COVID-19 patients at hospital admission. International Society on Thrombosis and Haemostasis (ISTH) 2021 Virtual Congress, July 17-21, 2021; Res Pract Thromb Haemost. 2021; 5 (Suppl 1). PB0206.

Lejeune M, Hekimian G, Masi P, Lebreton G, Chommeloux J, Desnos C, Pineton De Chambrun M, Martin-Toutain I, Nieszkowska A, Bréchot N, Schmidt M, Luyt CE, Leprince P, Combes A, Frere C. Longitudinal measurement of whole blood viscoelastic properties throughout the course of extracorporeal membrane oxygenation in COVID-19 patients with severe acute respiratory distress syndrome. International Society on Thrombosis and Haemostasis (ISTH) 2021 Virtual Congress, July 17-21, 2021; Res Pract Thromb Haemost. 2021; 5 (Suppl 1). PB0263.

Hulshof AM, van Oerle R, Henskens Y. Quantra: the influence of hematocrit, platelet count, Ringer lactate, and acetylsalicylic acid on viscoelastic properties of clot formation. International Society on Thrombosis and Haemostasis (ISTH) 2021 Virtual Congress, July 17-21, 2021; Res Pract Thromb Haemost. 2021; 5 (Suppl 1). PB0339. PB0263.

Karuppiah A, Kodali BS. Novel point of care rapid coagulation analyzer for obstetrics – Quantra (SEER sonorheometry. International Society on Thrombosis and Haemostasis (ISTH) 2021 Virtual Congress, July 17-21, 2021; Res Pract Thromb Haemost. 2021; 5 (Suppl 1). PB1306.

Winegar DA, Viola F. Is the Quantra QPlus system easy to interpret? American Association of Clinical Chemistry (AACC) Annual Scientific Meeting, Virtual Congress, December 13-17, 2020.

Baulig W, Akbas S, Schütt P, Berdat P, Theusinger OM. Comparison of the ultrasound sonorheometry based Quantra System with rotational thromboelastometry ROTEM Sigma in cardiac surgery. Euroanaesthesia 2020 Virtual Congress, Nov 28-30, 2020; Eur J Anaesthesiol. 2020;37 (e-Suppl.58):P4567.

Wurtz V, Scherrer V, Surlemont E, Gastaldi G, Bedoit E, Compère V, Veber B, Dureuil B, Rey N, Besnier E. Comparative evaluation of three point-of-care (POC) viscoelastic hemostasis systems in cardiac surgery: Quantra QPlus, ROTEM sigma and TEG 6s – Focus on fibrinogen and platelets. Société Française d’Anesthésie et de Réanimation (SFAR; French Society of Anesthesia and Intensive Care), Paris, France. September 24-26, 2020.

Damreh L, Winegar D, Viola F. Quantra reported stiffness values have a strong linear relationship with clot max stiffness. International Society on Thrombosis and Haemostasis (ISTH) 2020 Virtual Congress, July 12-14, 2020; Res Pract Thromb Haemost. 2020; 4 (Suppl 1).PB0694.

Lejeune M, Masi P, Desnos C, Pinton De Chambrun M, Chommeloux J, Martin-Toutain I, Nguyen G,Nieszkowska A, Bréchot N, Schmidt M, Luyt C-, Lefèvre I, Combes A, Hekimian G, Frere C. Comparison of a new point-of-care hemostasis analyzer with laboratory parameters in patients with veno-venous extracorporeal membrane oxygenation. International Society on Thrombosis and Haemostasis (ISTH) 2020 Virtual Congress, July 12-14, 2020; Res Pract Thromb Haemost. 2020; 4 (Suppl 1). PB0289.

Michelson E, Cripps M, Ray B, Winegar D, Viola F. Trauma-induced coagulopathy detected by the Quantra QStat system. 40th International Symposium on Intensive Care & Emergency Medicine (ISICEM), Brussels, Belgium. March 24-27, 2020; Crit Care. 2020;24 (Suppl. 1): P316.

Wentworth D, Portz BJ, Erdbruegger U. Coagulation differences in dialysis vascular access failure. American Society of Nephrology (ASN) Kidney Week 2019, Washington, DC, USA. November 5-10, 2019.

Shore-Lesserson L, Palleschi G, , Alaiev A, Waldman A, Sceppa EA, Dowling O. Evaluation of the Quantra hemostasis analyzer in obstetric patients at risk for bleeding. American Society of Anesthesiologists (ASA) Annual Meeting, Orlando, FL, USA. October 19-23, 2019.

Henderson R, Allen T, Viola F, Tanaka K. Quantra guided human fibrinogen concentrate dosing modeled after rotational thromboelastometry. American Society of Anesthesiologists (ASA) Annual Meeting, Orlando, FL, USA. October 19-23, 2019.

Winegar DA, Sudhagoni R, Allen TW, Viola F. Use of the Quantra QPlus system to predict fibrinogen and platelet transfusion thresholds in surgical patients. Society for the Advancement of Blood Management (SABM), Baltimore, MD, USA. September 19-21, 2019.

Paridaens MS , Angelo C, Mullier F , Chatelain B , Francois PM. Sonorheometry for point-of-care (POC) assessment of coagulation function in burned patient. Euroanaesthesia 2019, Vienna, Austria. June 1-3, 2019.

Baryshnikova E, Di Dedda U, Ranucci M. SEER sonorheometry and platelet function monitoring: a case report. Euroanaesthesia 2019, Vienna, Austria. June 1-3, 2019.

Allen TW, Viola F, Winegar DA. Intraoperative assessment of coagulation during cardiac surgery using the Quantra system and QPlus cartridge. Society of Cardiovascular Anesthesiologists(SCA), Chicago, IL, USA. May 18-21, 2019.

Groves D, Naik BI, Welsby IJ, Tanaka K, Hauck J, Greenberg C, Finley A, Winegar D, Viola F. Comparison of the Quantra system to a series of lab-based clinical composite indexes: a multi-center investigation. American Society of Anesthesiologists (ASA), San Francisco, CA, USA. October 13-17, 2018.

Hauck J, Welsby IJ, Groves D, Naik BI, Tanaka K, Finley A, Greenberg C, Viola F, Winegar D. Multi-center investigation of the clinical performance of the Quantra system vs. the ROTEM delta in surgical patients. American Society of Anesthesiologists (ASA), San Francisco, CA, USA October 13-17, 2018.

Braun P, Wang CW, Sekaran, Lloyd C, Givens T, Winegar D, Viola F. Performance of the Quantra hemostasis analyzer and QPlus cartridge: a new, rapid point-of-care device for assessment of coagulation using ultrasound. American Society of Anesthesiologists (ASA), San Francisco, CA, USA. October 13-17, 2018.

Zghaibe W, Besser M, Klein A, Scheuermann S, Blauszdin, Munting KA. Comparison of a novel point-of-care coagulation testing device (Quantra) with thromboelastography and laboratory testing. Association of Anaesthetists of Great Britain & Ireland(AAGBI), Dublin Ireland. September 26-28, 2018.

Zghaibe W, Besser M, Klein A, Munting K, Jones N, Curry S. Utility of the Quantra point-of-care coagulation testing device for guiding transfusion in cardiac surgery. European Association of Cardiothoracic Anaesthesiology (EACTA), Manchester, UK. September 19-21, 2018.

Winegar DA, Viola F, Washburn TB. Evaluation of the Quantra system vs TEG 5000 in cardiac surgery: a community-based hospital system experience. Society for the Advancement of Blood Management (SABM), New York, NY, USA. September 13-15, 2018.

Viola F, Wang C, Sekaran V, Brackett N, Braun P. A novel differential assay to quantify fibrinolytic function in whole blood with the Quantra hemostasis analyzer. Euroanaesthesia 2018, Copenhagen, Denmark. June 2-4, 2018.

Davis JPE, Intagliata NM, Shah NL, Caldwell SH and Northup, PG. In vitro monitoring of anticoagulation and coagulation profiles of cirrhotic patients with and without portal venous thrombosis: early results. Coagulation in Liver Diseases, Rome, Italy. October 6-7. 2017.

Viola F, Winegar DA, Fernandez LG, Groves DS, Huffmyer JL. Comparison of arterial and venous coagulation parameters measured with the Quantra system in cardiac surgery. International Society on Thrombosis and Haemostasis (ISTH) 2017 Congress. Berlin, Germany. July 8-13, 2017.

McLoughlin E, Ferrante EA, Viola F, Maitland H. Sonic estimation of elasticity via resonance (SEER) sonorheometry to identify hypercoagulability in patients with cancer. International Society on Thrombosis and Haemostasis (ISTH) 2017 Congress. Berlin, Germany. July 8-13, 2017.

Viola F, Lloyd C, Higgins T, Homyk A, Bryant D, Givens T, Braun P. The Quantra surgical cartridge: a novel assay for the rapid assessment of coagulation function from whole blood. International Society on Thrombosis and Haemostasis (ISTH) 2017 Congress. Berlin, Germany. July 8-13, 2017.

Braun P, Wang C, Sekaran V, Koren M, Lloyd C, Viola F. Performance evaluation of the Quantra surgical cartridge for rapid point-of-care (POC) assessment of coagulation function. Presented at the International Society on Thrombosis and Haemostasis 2017 Congress. Berlin, Germany. July 8-13, 2017.

Viola F, Winegar DA, Fernandez LG, Huffmyer JL, Groves DS. Comparison of Quantra vs ROTEM Delta and routine coagulation tests in cardiac surgery. Presented at Euroanaesthesia 2017. Geneva, Switzerland. June 3-5, 2017.

Society of Thoracic Surgeons/Society of Cardiovascular Anesthesiologists: 2011 update to the Society of Thoracic Surgeons and the Society of Cardiovascular Anesthesiologists blood conservation clinical practice guidelines
View on PubMed

Practice Guidelines for Perioperative Management: An Updated Report by the American Society of Anesthesiologists Task Force on Perioperative Blood Management
View PDF

Society for the Advancement of Blood Management: Diagnostic Testing in Patient Blood Management Programs
View PDF

Management of Severe Perioperative Bleeding: Guidelines from the European Society of Anaesthesiology
View Now