CLINICAL APPLICATIONS

Scientific Publications

Explore publications on viscoelastic testing, the Quantra device and its sonorheometry technology, Quantra testing in various clinical domains, and patient blood management (PBM) guidelines.

Heubner L, Mirus M, Vicent O, Güldner A, Tiebel O, Beyer-Westendorf J, Fries D, Spieth PM. Point of care coagulation management in anesthesiology and critical care. Minerva Anestesiol. 2022;88:615-628.

Volod O, Bunch CM , Zackariya N, Moore EE, Moore HB, Kwaan HC, Neal MD, Al-Fadhl MD, Patel SS, Wiarda G, Al-Fadhl HD, McCoy ML, Thomas AV, Thomas SG, Gillespie L, Khan RZ, Zamlut M, Kamphues P, Fries D, Walsh MM. Viscoelastic Hemostatic Assays: A Primer on Legacy and New Generation Devices. J. Clin. Med. 2022;11:860.

Faraoni D, DiNardo JA. Viscoelastic hemostatic assays: Update on technology and clinical applications. Am J Hematol. 2021;96:1331-1337.

Carll T, Wool GD. Basic principles of viscoelastic testing. Transfusion. 2020;60(Suppl 6):S1-S9.

Tanaka KA, Henderson RA, Strauss ER. Evolution of viscoelastic coagulation testing. Expert Rev Hematol. 2020;13:697-707.

Volod O , Francesco Viola F. The Quantra System: System Description and Protocols for Measurements. Methods Mol Biol. 2023;2663:743-761.

Allen T.W., Winegar D., Viola F. (2021) The Quantra^® System and SEER Sonorheometry. In: Moore H.B., Neal M.D., Moore E.E. (eds) Trauma induced coagulopathy. Springer, Cham.

Leadbetter NH, Givens TB, Viola F. Unique Approach to Quality Assurance in Viscoelastic Testing. J Appl Lab Med. 2020;5:1228-1241.

Allen TW, Viola F. A novel point-of-care approach for improving acute bleeding management. MLO Med Lab Obs.2018 Aug;50(9); 30-34.

Ferrante EA, Blasier KR, Givens TB, Lloyd CA, Fischer TJ, Viola F. A Novel Device for the Evaluation of Hemostatic Function in Critical Care Settings. Anesth Analg. 2016; 123(6):p 1372-1379.

Sniecinski RM, Tanaka KA. SEER Sonorheometry: Listening to What the Clot Has to Say. Anesth Analg. 2016;123:1346-1347.

Wanderer JP, Nathan N. From Liquid to Solid: Evaluating Clot Strength. Anesth Analg. 2016;123(6):p 1345.

Viola F, Lin-Schmidt X, Bhamidipati C, Haverstick DM, Walker WF, Ailawadi G, Lawrence MB. Sonorheometry assessment of platelet function in cardiopulmonary bypass patients: Correlation of blood clot stiffness with platelet integrin α_IIbβ₃ activity, aspirin usage, and transfusion risk Thromb Res. 2016;138:96-102.

Corey FS, Walker WF. Sonic Estimation of Elasticity via Resonance: A New Method of Assessing Hemostasis. Ann Biomed Eng. 2015;44:1405-24.

Mauldin FW, Viola F, Hamer TC, Ahmed EM, Crawford SB, Haverstick DM, Lawrence MB, Walker WF. Adaptive force sonorheometry for assessment of whole blood coagulation. Clin Chim Acta. 2010;411:638-644.

Viola F, Mauldin FW, Lin-Schmidt X, Haverstick DM, Lawrence MB, Walker WF. A novel ultrasound-based method to evaluate hemostatic function of whole blood. Clin Chim Acta. 2010;411:106-113.

Mauldin WF, Viola F, Walker WF. Complex principal components for robust motion estimation. IEEE Trans Ultrason Ferroelec Freq Control. 2010;57:2437-2449.

Viola F, Kramer MD, Lawrence MB, Oberhauser JP, Walker WF. Sonorheometry: A Noncontact Method for the Dynamic Assessment of Thrombosis. Ann Biomed Eng. 2004;32:696-705.

Cardiac Surgery

Tibi P, Thompson J, Attaran S, Black E. Retrospective study assessing outcomes in cardiac surgery after implementation of Quantra. J Cardiothorac Surg. 2023;18:149.

Tiquet B, Pihan F, Thomasset P, Denizou M, Tifrea M, Tifrea A,1 Orsel I, Marsaud JP, Jouan J, Vandroux D. Clues of incomplete reversal of heparin in cardiac surgery. Perfusion. 2023 Feb 22 [Online ahead of print].

Demailly Z, Wurtz V, Barbay V, Surlemont E, Scherrer V, Compère V, Billoir P, Clavier T, Besnier E. Point-of-Care Viscoelastic Hemostatic Assays in Cardiac Surgery Patients: Comparison of Thromboelastography 6S, Thromboelastometry Sigma, and Quantra. J Cardiothorac Vasc Anesth 2023;37:948-955.

Zlotnik D, Abdallah GA, Lang E, Boucebci KJ, Gautier CH, François A, Gaussem P, Godier A. Assessment of a Quantra-Guided Hemostatic Algorithm in High-Bleeding-Risk Cardiac Surgery. J Cardiothorac Vasc Anesth. 2023;37:724-731.

Baryshnikova E, Di Dedda U, Ranucci M. Are Viscoelastic Tests Clinically Useful to Identify Platelet-Dependent Bleeding in High-Risk Cardiac Surgery Patients? Anesth Analg. 2022;135(6):p 1198-1206.

Baulig W, Akbas S, Schütt PK, Keul W, Jovic M, Berdat P, von Felten S, Steigmiller K, Ganter MT, Theusinger OM. Comparison of the resonance sonorheometry based Quantra^® system with rotational thromboelastometry ROTEM^® sigma in cardiac surgery - a prospective observational study. BMC Anesthesiol. 2021;21:260.

Bolliger D, Kamber F, Mauermann E. Same but Different: Viscoelastic Hemostatic Assays in Cardiac Surgery.J Cardiothorac Vasc Anesth. 2021;35:1037-1039.

Yates SG, DeAnda A. Same but Different: Viscoelastic Hemostatic Assays in Cardiac Surgery. J Cardiothorac Vasc Anesth. 2022;36:637-638.

DeAnda A, Levy G, Kinsky M, Sanjoto P, Garcia M, Avandsalehi KR, Diaz G, Yates SG. Comparison of the Quantra QPlus System With Thromboelastography in Cardiac Surgery. J Cardiothorac Vasc Anesth. 2021;35:1030-1036.

Naik BI, Tanaka K, Sudhagoni RG, Viola F. Prediction of hypofibrinogenemia and thrombocytopenia at the point of care with the Quantra^® QPlus^® System. Thromb Res. 2021;197:88-93.

Groves DS, Welsby IJ, Naik BI, Tanaka K, Hauck JN, Greenberg CS, Winegar DA, Viola F. Multicenter Evaluation of the Quantra QPlus System in Adult Patients Undergoing Major Surgical Procedures. Anesth Analg. 2020;130:899-909.

Zghaibe W, Scheuermann S, Munting K, Blaudszun G, Besser M, Ortmann E, Klein AA. Clinical utility of the Quantra^® point-of-care haemostasis analyser during urgent cardiac surgery. Anaesthesia. 2020;75:366-373.

Michel S, Piekarski F, Fischer JH, Hettler V, Adam EH, Holzer L, Lotz G, Walther T, Zacharowski K, Raimann FJ. Hemostatis Analyzer-Supported Hemotherapy Algorithm in Cardiac Surgery: Protocol for a Randomized Controlled Monocentric Trial. JMIR Res Protoc. 2020;9:e17206.

Groves DS, Winegar DA, Fernandez LG, Huffmyer JL, Viola F. Comparison of Coagulation Parameters in Arterial and Venous Blood in Cardiac Surgery Measured Using the Quantra System J Cardiothorac Vasc Anesth. 2019;33:976-984.

Bolliger D, Kenichi A Tanaka KA. Platelet Count and Function-Can We Kill Two Birds With an Ultrasound Wave? J Cardiothorac Vasc Anesth. 2019;33:1599-1600.

Baryshnikova E, Di Dedda U, Ranucci M. A Comparative Study of SEER Sonorheometry Versus Standard Coagulation Tests, Rotational Thromboelastometry, and Multiple Electrode Aggregometry in Cardiac Surgery. J Cardiothorac Vasc Anesth. 2019;33:1590-1598.

Huffmyer JL, Fernandez LG, Haghighian C, Terkawi AS, Groves DS. Comparison of SEER Sonorheometry With Rotational Thromboelastometry and Laboratory Parameters in Cardiac Surgery. Anesth Analg. 2016;123:1390-1399.

Reynolds PS, Middleton P, McCarthy H, Spiess B. A Comparison of a New Ultrasound-Based Whole Blood Viscoelastic Test (SEER Sonorheometry) Versus Thromboelastography in Cardiac Surgery. Anesth Analg. 2016;123:1400-1407.

Liver Transplantation

Barroso A, Martinez-Gonzalez M, Knowlson N, Miguel AM, Perez G. Perioperative myocardial infarction following dabigatran reversal with Idarucizumab in a patient undergoing orthotopic liver transplantation. Cureus 2023;15:e43531.

Flores AS, Forkin KT, Brennan MM, Kumar SS, Winegar DA,Viola F. Multicenter evaluation of the Quantra with the QStat Cartridge in adult patients undergoing liver transplantation. Liver Transpl. 2023 Mar 29 [Online ahead of print].

Other Surgery

Bergman ZR, Robbins AJ, Alwan FS, Bellin MD, Kirchner VA, Pruett TL, Mulier KE, Boucher AA, Lusczek ER, Beilman GJ. Perioperative Coagulation Changes in Total Pancreatectomy and Islet Autotransplantation. Pancreas. 2022;51:671-677.

Idowu O, Ifeanyi-Pillette I, Owusu-Agyemang P, Holmes A, Kwater P, Jackson T, Mena G, Lasala J, Heir JS. The quantra hemostasis analyzer compared to thromboelastography (TEG) in the surgical oncologic population: A prospective observational trial. J Surg Oncol. 2021;124:894-905.

Naik BI, Durieux ME, Knisely A, Sharma J, Bui-Huynh VC, Yalamuru B, Terkawi AS, Nemergut EC. SEER Sonorheometry Versus Rotational Thromboelastometry in Large Volume Blood Loss Spine Surgery. Anesth Analg. 2016;123(6):p 1380-1389.

Trauma

Rossetto A, Wohlgemut JM, Brohi K, Davenport R. Sonorheometry versus rotational thromboelastometry in trauma: a comparison of diagnostic and prognostic performance. J Thromb Haemost. 2023;21:2114-2125.

Duclos G, Fleury M, Grosdidier C, Lakbar I, Antonini F, Lassale B, Arbelot C, Albaladejo P, Zieleskiewicz L, Marc Leone M. Blood coagulation test abnormalities in trauma patients detected by sonorheometry: a retrospective cohort study. Res Pract Thromb Haemost. 2023;7:e100163.

Michelson EA, Cripps MW, Ray B, Winegar DA, Viola F. Initial clinical experience with the Quantra QStat System in adult trauma patients. Trauma Surg Acute Care Open 2020;5:e000581.

Whyte CS, Rastogi A, Ferguson E, Donnarumma M, Mutch NJ. The Efficacy of Fibrinogen Concentrates in Relation to Cryoprecipitate in Restoring Clot Integrity and Stability against Lysis. Int J Mol Sci. 2022;23:2944.

Obstetrics

Gonzalez-Fiol A, Fardelmann KL, Yanez D, Salimi N, Mancini P, Alian A. Comparison between the Rotational Thromboelastometry (ROTEM) Delta device against the Cartridge-based Thromboelastography 6s and Quantra in a healthy third trimester pregnant cohort. J Clin Monit Comput. 2023;37:267-273.

Kodali BS, Karuppiah A, Bharadwaj S, Chow J, Tanaka K. Efficacy of sonorheometry point of the care device in determining low fibrinogen levels in pregnant blood: an invitro dilution and reconstitution study. J Clin Monit Comput. 2022;36:1423-1431.

COVID-19

López-Jaime FJ, Fernández-Bello I, Martín-Téllez S, Doblas-Márquez A, Tesfay Y, Márquez-Gómez I, a Reguera-Iglesias JM, Muñoz-Pérez MI, Montaño A. Clot Stiffness Measured By Seer Sonorheometry As a Marker Of Poor Prognosis In Hospitalized COVID-19 Patients. Clin Appl Thromb Hemost. 2022;28:10760296221112085.

Billoir P, Leprêtre P, Thill C, , Bellien J, , Le Cam Duchez V, Selim J, Tamion F, Clavier T, Besnier E. Routine and Advanced Laboratory Tests for Hemostasis Disorders in COVID-19 Patients: A Prospective Cohort Study. J. Clin. Med. 2022;11:1383.

Baryshnikova E. (2022) Point-of-Care Coagulation Tests in COVID-19. In: Ranucci M. (eds) The coagulation labyrinth of Covid-19. Springer, Cham

Bareille M, Hardy M, Douxfils J, Roullet S, Lasne D, Jerrold H Levy JH, Stépanian A, Susen S, Frère C, Lecompte T, Mullier F . Viscoelastometric Testing to Assess Hemostasis of COVID-19: A Systematic Review. J Clin Med. 2021;10:1740.

Rodrigues A, Sevivas TS, Pereira CL, Caiado A, Nunes AR. Viscoelastic Tests in the Evaluation of Haemostasis Disturbances in SARS-CoV2 Infection. Acta Med Port. 2021;34:44-55.

Pacheco LD, Berry M , Saad AF, Yates SG, Saade GR. Coagulation assessment with viscoelastic testing in asymptomatic postpartum patients with SARS-CoV-2 infection: a pilot study. Am J Obstet Gynecol. 2021;225:575-577.

Ranucci M, Ballotta A, Di Dedda U, Bayshnikova E, Dei Poli M, Resta M, Falco M, Albano G, Menicanti L. The procoagulant pattern of patients with COVID-19 acute respiratory distress syndrome. J Thromb Haemost. 2020;18:1747-1751.

Masi P, Hékimian G, Lejeune M, Chommeloux J, Desnos C, Pineton De Chambrun M, Martin-Toutain I, Nieszkowska A, Lebreton G, Bréchot N, Schmidt M, Luyt CE, Combes A, Frere C. Systemic Inflammatory Response Syndrome Is a Major Contributor to COVID-19-Associated Coagulopathy: Insights From a Prospective Single-Center Cohort Study. Circulation. 2020;142:611-614.

Pediatrics

Tumber S, Stondell C, Wilson M, Tsang Yang N, Tafoya S. Reference values in healthy children using the Quantra Hemostasis Analyzer, a novel point of care viscoelastic testing device. Paediatr Anaesth. 2022;32:1370-1371.

2022

Baryshnikova E, Di Dedda U, Ranucci M. The Quantra PCS, platelet contribution to clot stiffness, parameter is clinically useful to identify platelet dependent bleeding in high-risk cardiac surgery patients. European Association of Cardiothoracic Anaesthesiology and Intensive Care (EACTAIC) Annual Congress, Naples, Italy; December 14-16, 2022.
J Cardiothorac Vasc Anesth. 2022;36:S35-S36.

Afraz S, Das A, Paulino S, Odeh J, Shi C, Sarode R, Yates S. Method comparison analysis of Quantra relative to rotational thromboelastometry and conventional coagulation testing in cardiac surgery. American Society of Hematology (ASH) Annual Meeting, New Orleans, LA, USA; December 10-13, 2022. Blood. 2022;140 (Supplement 1):11289–11290.

Grosland J, Kiberenge R, Todd M. Initial clinical experience with the Quantra System with the QStat Cartridge in liver transplantation. American Society of Anesthesiologists (ASA) Annual Meeting, New Orleans, LA, USA; October 21-26, 2022.

Tirotta C, Ojito J, Lim H, Lagueruela RG, Burke R, Evaluation of Quantra QPlus in pediatric cardiac surgery. Pediatric cardiac surgery. American Society of Anesthesiologists (ASA) Annual Meeting, New Orleans, LA, USA; October 21-26, 2022.

Flores AS, Brennan M, Kumar S, Forkin KT, Winegar DA, Viola F. Multicenter investigation of the Quantra System with the QStat Cartridge in liver transplant recipients. American Society of Anesthesiologists (ASA) Annual Meeting, New Orleans, LA, USA; October 21-26, 2022.

Burns J, Alberts MS, Anderson CA. Use of a novel POC coagulation device to provide real-time transfusion needs and reduce overall transfusion rates in cardiac surgery. Cardiothoracic Research and Education Forum (CREF) 41^st Cardiothoracic Surgery Symposium, San Diego, CA, USA; October 19-23, 2022.

De Giorgis V, Dolcino A, Piat C, Tientcheu Yamgueu M, Barbanti C. Sonorhéométrie par résonance (SEER)-Quantra en chirurgie cardiaque pédiatrique. Société Française d’Anesthésie et de Réanimation (SFAR; French Society of Anesthesia and Intensive Care), Paris, France; September 22-24, 2022.

Foufa MH, Gouezel C, Jendoubi A, De Tymowski C, Mariani L, Do Vale J, Roue M, Carrasco Del Castillo JL, Mellano V, Kantor E, Rozencwajg S, Sutterlin L, Elbaz L, Dilly MP, Provenchère S, Mignon A, Longrois D, Montravers P. Relation entre la composante plaquettaire de l’élasticité du caillot explorée par le moniteur Quantra et la numération plaquettaire en fin de chirurgie cardiaque chez l’adulte. Société Française d’Anesthésie et de Réanimation (SFAR; French Society of Anesthesia and Intensive Care), Paris, France; September 22-24, 2022.

Lukowiak O, Le Gouez A, Djebbour M, Mercier F, Bouthors AS. Normes de référence du système d’hémostase délocalisée Quantra QStat en fin de grossesse normale et en postpartum immédiat. Résultats préliminaires. Société Française d’Anesthésie et de Réanimation (SFAR; French Society of Anesthesia and Intensive Care), Paris, France; September 22-24, 2022.

Duclos G, Fleury M, Antonini F, Grosdidier C, Arbelot C, Leone M. Apport du système Quantra la prise en charge du traumatisé grave. Société Française d’Anesthésie et de Réanimation (SFAR; French Society of Anesthesia and Intensive Care), Paris, France; September 22-24, 2022.

Rossetto A, Wohlgemut JM, Fischer F, Brohi K, Davenport R. Sonorheometry versus rotational thromboelastometry in trauma. American Association for the Surgery of Trauma (AAST) Annual Meeting, Chicago, IL, USA; September 21-24, 2022.

Winegar D, Gillespie C, Sanchez-Illan M. Improving the interpretation of viscoelastic test results in the critical care setting. American Association of Clinical Chemistry (AACC) Annual Scientific Meeting, Chicago, IL, USA; July 24-28, 2022.

Handel E, Smith W, Wang C, Toffaletti J. Precision of HemoSonics Quantra QStat Cartridge to determine coagulation function and fibrinolytic status of samples assessed at 3 locations within medical center. American Association of Clinical Chemistry (AACC) Annual Scientific Meeting, Chicago, IL, USA; July 24-28, 2022.

Whyte C, Rastogi A, Ferguson E, Donnarumma M, Mutch N. Comparison of fibrinogen concentrates to cryoprecipitate in restoring clot integrity and stability against fibrinolytic degradation. International Society on Thrombosis and Haemostasis (ISTH) 2022 Congress, London, UK; July 9-13, 2022. Res Pract Thromb Haemost. 2022;6(Suppl.1). PB0624.

Teissandier D, Lucchini C, Bouillon-Minois J, Schmidt J, Sinegre T, Morand C, Lebreton A, Moustafa F. Assessment of Quantra Analyzer on life-threating bleeding under oral anticoagulants agents: a pilot study. International Society on Thrombosis and Haemostasis (ISTH) 2022 Congress, London, UK; July 9-13, 2022. Res Pract Thromb Haemost. 2022;6(Suppl.1). PB1015.

Wahl C, Cornillot C, Maison M, Lhotellier L, Yangaju K, Dalibard M, Macraigne L, Lopez V, Chhing A, Frere C, Saheb S. Evaluation of the ultrasound sonorheometry based Quantra System to monitor hemostasis in patients undergoing plasma exchange therapy. International Society on Thrombosis and Haemostasis (ISTH) 2022 Congress, London, UK; July 9-13, 2022. Res Pract Thromb Haemost. 2022;6(Suppl.1). PB1072.

Llau JV, Madrid E, MartÍnez E, Narváez L, Galarreta M, Armero R. Procoagulant pattern of COVID-19 patients at ICU admission assessed by new viscoelastic test device Quantra. Euroanaesthesia 2022, Milan, Italy; June 4-6, 2022.
Eur J Anaesthesiol. 2022;(e-Suppl. 60):247 (abstract 12AP01-07).

2021

Tiquet B, Pihan F, Tifrea M, Tifrea A, Denizou M, Philippe P, Orsel I, Marsaud JP, Jouan J, Vandroux D. Intraoperative validity of point of care during partial heparin neutralization. European Association of Cardiothoracic Anaesthesiology and Intensive Care (EACTAIC) and International Congress of Cardiothoracic and Vascular Anesthesia (ICCVA) Joint Virtual Congress; October 27-29, 2021. J Cardiothorac Vasc Anesth. 2021;35:S12.

Roussiaux A, Halchini C, Ducrocq N, Bigeon JY, Burtin P, Lorne E. Retrospective evaluation of economy in blood products transfusion for cardiac surgery patients thanks to a point-of-care viscoelastic test. American Society of Anesthesiologists (ASA) Annual Meeting, San Diego, CA, USA; October 8-12, 2021.

Salimi N, Gonzalez-Fiol A, Fardelmann KL, Yanez D, Abdel-Razeq S, Alian AA. Comparing the use of Quantra vs. rotational thromboelastometry for point of care viscoelastic testing. American Society of Anesthesiologists (ASA) Annual Meeting, San Diego, CA, USA; October 8-12, 2021.

Idowu O, Ifeanyi-Pillette IC, Owusu-Agyemang P, Allen Holmes A, Jackson TA, Kwater PA, Mena GE, Lasala JD, Heir JS. A new solution to an old problem: Sonic Estimation of Elasticity via Resonance (SEER) sonorheometry technology versus thromboelastography (TEG) in a surgical oncological population. American Society of Anesthesiologists (ASA) Annual Meeting, San Diego, CA, USA; October 8-12, 2021.

Idowu T, Williams WH, Purugganan R, Wright CC, Caldero TM, Vachhani S, Tsai J, Mirza KH, Heir JS. A comparison of the Quantra and TEG 5000 devices in patients undergoing oncologic surgeries with intraoperative hemorrhage at a high volume cancer center. American Society of Anesthesiologists (ASA) Annual Meeting, San Diego, CA, USA; October 8-12, 2021.

Roussiaux A, Bigeon JY, Halchini C, Burtin P, Ducrocq N, Lorne E. Retrospective evaluation of economy in blood products transfusion for cardiac surgery patients thanks to a point-of-care viscoelastic test. European Society of Intensive Care Medicine ESICM LIVES 2021, Virtual Congress; October 3 – 6, 2021. Intensive Care Med Exp. 2021;9:000801.

Gouëzel C, Dilly MP, Roué M, Portefaix H, Voulgaropoulos J, Mellano V, Succar E, Ibrahim H, Stern J, De Tymowski C, Papin G, Carrasco JL, Do Vale J, Jendoubi A, Copelovici L, Foufa H, Montravers P, Provenchère S, Longrois D. Analyse en composante principale des résultats des tests visco-élastiques (TVE) et des tests de laboratoire chez des patients de chirurgie cardiaque. Société Française d’Anesthésie et de Réanimation (SFAR; French Society of Anesthesia and Intensive Care), Paris, France; September 23-25, 2021.

Abi Abdallah G, Zlotnik D, Boucebci K, De La Barre H, Du Puy-Montbrun L, François A, Gaussem P, Godier A. Clinical assessment of the Quantra^® point-of-care hemostasis testing in high-risk of bleeding cardiac surgery. Société Française d’Anesthésie et de Réanimation (SFAR; French Society of Anesthesia and Intensive Care), Paris, France; September 23-25, 2021.

Roussiaux A, Halchini C, Ducrocq N, Burtin P, Lorne E. Évaluation rétrospective de l’ économie transfusionnelle en chirurgie cardiaque à l’ aide d’ un test viscoéelastique point-of-care. Société Française d’Anesthésie et de Réanimation (SFAR; French Society of Anesthesia and Intensive Care), Paris, France; September 23-25, 2021.

Wohlgemut JM, Rossetto A, Davenport R. Compariosn of alternative hemostatic assays – rotational thromboelastometry versus sonorheometry for rapid diagnosis in trauma patients: an interim analysis. International Society on Thrombosis and Haemostasis (ISTH) 2021 Virtual Congress, July 17-21, 2021; Res Pract Thromb Haemost. 2021; 5 (Suppl 1). OC45.2.

Abbes A, Frere C, Loeb J, Djavidi N, Lebreton G, Bougle A. A comparative study of SEER sonorheometry versus thromboelastography during cardiac surgery with cardiopulmonary bypass. International Society on Thrombosis and Haemostasis (ISTH) 2021 Virtual Congress, July 17-21, 2021; Res Pract Thromb Haemost. 2021; 5 (Suppl 1). PB0080.

Washburn Jr TB, Houdijk W, Sudhagoni R. Preoperative measurement of platelet contribution to clot stiffness (PCS) with the Quantra^® QPlus system and bleeding after cardiac surgery. International Society on Thrombosis and Haemostasis (ISTH) 2021 Virtual Congress, July 17-21, 2021; Res Pract Thromb Haemost. 2021; 5 (Suppl 1). LPB0107.

López Jaime FJ, Martín-Téllez S, Doblas-Márquez A, Márquez-Gómez I, Alemany J, Pérez-Raya M, Mena-Santano AM, Muñoz-López DF, Muñoz-Pérez MI, Fernández-Bello I, Montaño A. Hypercoagulability detected by SEER sonorheometry in COVID-19 patients at hospital admission. International Society on Thrombosis and Haemostasis (ISTH) 2021 Virtual Congress, July 17-21, 2021; Res Pract Thromb Haemost. 2021; 5 (Suppl 1). PB0206.

Lejeune M, Hekimian G, Masi P, Lebreton G, Chommeloux J, Desnos C, Pineton De Chambrun M, Martin-Toutain I, Nieszkowska A, Bréchot N, Schmidt M, Luyt CE, Leprince P, Combes A, Frere C. Longitudinal measurement of whole blood viscoelastic properties throughout the course of extracorporeal membrane oxygenation in COVID-19 patients with severe acute respiratory distress syndrome. International Society on Thrombosis and Haemostasis (ISTH) 2021 Virtual Congress, July 17-21, 2021; Res Pract Thromb Haemost. 2021; 5 (Suppl 1). PB0263.

Hulshof AM, van Oerle R, Henskens Y. Quantra: the influence of hematocrit, platelet count, Ringer lactate, and acetylsalicylic acid on viscoelastic properties of clot formation. International Society on Thrombosis and Haemostasis (ISTH) 2021 Virtual Congress, July 17-21, 2021; Res Pract Thromb Haemost. 2021; 5 (Suppl 1). PB0339. PB0263.

Karuppiah A, Kodali BS. Novel point of care rapid coagulation analyzer for obstetrics – Quantra (SEER sonorheometry. International Society on Thrombosis and Haemostasis (ISTH) 2021 Virtual Congress, July 17-21, 2021; Res Pract Thromb Haemost. 2021; 5 (Suppl 1). PB1306.

2020

Winegar DA, Viola F. Is the Quantra QPlus system easy to interpret? American Association of Clinical Chemistry (AACC) Annual Scientific Meeting, Virtual Congress, December 13-17, 2020.

Baulig W, Akbas S, Schütt P, Berdat P, Theusinger OM. Comparison of the ultrasound sonorheometry based Quantra System with rotational thromboelastometry ROTEM Sigma in cardiac surgery. Euroanaesthesia 2020 Virtual Congress, Nov 28-30, 2020; Eur J Anaesthesiol. 2020;37 (e-Suppl.58):P4567.

Wurtz V, Scherrer V, Surlemont E, Gastaldi G, Bedoit E, Compère V, Veber B, Dureuil B, Rey N, Besnier E. Comparative evaluation of three point-of-care (POC) viscoelastic hemostasis systems in cardiac surgery: Quantra QPlus, ROTEM sigma and TEG 6s – Focus on fibrinogen and platelets. Société Française d’Anesthésie et de Réanimation (SFAR; French Society of Anesthesia and Intensive Care), Paris, France. September 24-26, 2020.

Damreh L, Winegar D, Viola F. Quantra reported stiffness values have a strong linear relationship with clot max stiffness. International Society on Thrombosis and Haemostasis (ISTH) 2020 Virtual Congress, July 12-14, 2020; Res Pract Thromb Haemost. 2020; 4 (Suppl 1).PB0694.

Lejeune M, Masi P, Desnos C, Pinton De Chambrun M, Chommeloux J, Martin-Toutain I, Nguyen G,Nieszkowska A, Bréchot N, Schmidt M, Luyt C-, Lefèvre I, Combes A, Hekimian G, Frere C. Comparison of a new point-of-care hemostasis analyzer with laboratory parameters in patients with veno-venous extracorporeal membrane oxygenation. International Society on Thrombosis and Haemostasis (ISTH) 2020 Virtual Congress, July 12-14, 2020; Res Pract Thromb Haemost. 2020; 4 (Suppl 1). PB0289.

Michelson E, Cripps M, Ray B, Winegar D, Viola F. Trauma-induced coagulopathy detected by the Quantra QStat system. 40th International Symposium on Intensive Care & Emergency Medicine (ISICEM), Brussels, Belgium. March 24-27, 2020; Crit Care. 2020;24 (Suppl. 1): P316.

2019

Wentworth D, Portz BJ, Erdbruegger U. Coagulation differences in dialysis vascular access failure. American Society of Nephrology (ASN) Kidney Week 2019, Washington, DC, USA. November 5-10, 2019.

Shore-Lesserson L, Palleschi G, , Alaiev A, Waldman A, Sceppa EA, Dowling O. Evaluation of the Quantra hemostasis analyzer in obstetric patients at risk for bleeding. American Society of Anesthesiologists (ASA) Annual Meeting, Orlando, FL, USA. October 19-23, 2019.

Henderson R, Allen T, Viola F, Tanaka K. Quantra guided human fibrinogen concentrate dosing modeled after rotational thromboelastometry. American Society of Anesthesiologists (ASA) Annual Meeting, Orlando, FL, USA. October 19-23, 2019.

Winegar DA, Sudhagoni R, Allen TW, Viola F. Use of the Quantra QPlus system to predict fibrinogen and platelet transfusion thresholds in surgical patients. Society for the Advancement of Blood Management (SABM), Baltimore, MD, USA. September 19-21, 2019.

Paridaens MS , Angelo C, Mullier F , Chatelain B , Francois PM. Sonorheometry for point-of-care (POC) assessment of coagulation function in burned patient. Euroanaesthesia 2019, Vienna, Austria. June 1-3, 2019.

Baryshnikova E, Di Dedda U, Ranucci M. SEER sonorheometry and platelet function monitoring: a case report.Euroanaesthesia 2019, Vienna, Austria. June 1-3, 2019.

Allen TW, Viola F, Winegar DA. Intraoperative assessment of coagulation during cardiac surgery using the Quantra system and QPlus cartridge. Society of Cardiovascular Anesthesiologists(SCA), Chicago, IL, USA. May 18-21, 2019.

2018

Groves D, Naik BI, Welsby IJ, Tanaka K, Hauck J, Greenberg C, Finley A, Winegar D, Viola F. Comparison of the Quantra system to a series of lab-based clinical composite indexes: a multi-center investigation. American Society of Anesthesiologists (ASA), San Francisco, CA, USA. October 13-17, 2018.

Hauck J, Welsby IJ, Groves D, Naik BI, Tanaka K, Finley A, Greenberg C, Viola F, Winegar D. Multi-center investigation of the clinical performance of the Quantra system vs. the ROTEM delta in surgical patients. American Society of Anesthesiologists (ASA), San Francisco, CA, USA October 13-17, 2018.

Braun P, Wang CW, Sekaran, Lloyd C, Givens T, Winegar D, Viola F. Performance of the Quantra hemostasis analyzer and QPlus cartridge: a new, rapid point-of-care device for assessment of coagulation using ultrasound. American Society of Anesthesiologists (ASA), San Francisco, CA, USA. October 13-17, 2018.

Zghaibe W, Besser M, Klein A, Scheuermann S, Blauszdin, Munting KA. Comparison of a novel point-of-care coagulation testing device (Quantra) with thromboelastography and laboratory testing. Association of Anaesthetists of Great Britain & Ireland(AAGBI), Dublin Ireland. September 26-28, 2018

Zghaibe W, Besser M, Klein A, Munting K, Jones N, Curry S. Utility of the Quantra point-of-care coagulation testing device for guiding transfusion in cardiac surgery. European Association of Cardiothoracic Anaesthesiology (EACTA), Manchester, UK. September 19-21, 2018.

Winegar DA, Viola F, Washburn TB. Evaluation of the Quantra system vs TEG 5000 in cardiac surgery: a community-based hospital system experience. Society for the Advancement of Blood Management (SABM), New York, NY, USA. September 13-15, 2018.

Viola F, Wang C, Sekaran V, Brackett N, Braun P. A novel differential assay to quantify fibrinolytic function in whole blood with the Quantra hemostasis analyzer. Euroanaesthesia 2018, Copenhagen, Denmark. June 2-4, 2018.

2017

Davis JPE, Intagliata NM, Shah NL, Caldwell SH and Northup, PG. In vitro monitoring of anticoagulation and coagulation profiles of cirrhotic patients with and without portal venous thrombosis: early results. Coagulation in Liver Diseases, Rome, Italy. October 6-7. 2017.

Viola F, Winegar DA, Fernandez LG, Groves DS, Huffmyer JL. Comparison of arterial and venous coagulation parameters measured with the Quantra system in cardiac surgery. International Society on Thrombosis and Haemostasis (ISTH) 2017 Congress. Berlin, Germany. July 8-13, 2017.

McLoughlin E, Ferrante EA, Viola F, Maitland H. Sonic estimation of elasticity via resonance (SEER) sonorheometry to identify hypercoagulability in patients with cancer. International Society on Thrombosis and Haemostasis (ISTH) 2017 Congress. Berlin, Germany. July 8-13, 2017.

Viola F, Lloyd C, Higgins T, Homyk A, Bryant D, Givens T, Braun P. The Quantra surgical cartridge: a novel assay for the rapid assessment of coagulation function from whole blood. International Society on Thrombosis and Haemostasis (ISTH) 2017 Congress. Berlin, Germany. July 8-13, 2017.

Braun P, Wang C, Sekaran V, Koren M, Lloyd C, Viola F. Performance evaluation of the Quantra surgical cartridge for rapid point-of-care (POC) assessment of coagulation function. Presented at the International Society on Thrombosis and Haemostasis 2017 Congress. Berlin, Germany. July 8-13, 2017.

Viola F, Winegar DA, Fernandez LG, Huffmyer JL, Groves DS. Comparison of Quantra vs ROTEM Delta and routine coagulation tests in cardiac surgery. Presented at Euroanaesthesia 2017. Geneva, Switzerland; June 3-5, 2017.

Perioperative

Kietaibl S, Ahmed A, Arash Afshari A, et al. Management of severe peri-operative bleeding: Guidelines from the European Society of Anaesthesiology and Intensive Care: Second update 2022. Eur J Anaesthesiol. 2023;40:226-304.

Tibi P, R McClure S, Huang J, et al. STS/SCA/AmSECT/SABM Update to the Clinical Practice Guidelines on Patient Blood Management. Ann Thorac Surg. 2021;112:981-1004.

Raphael J, Mazer CD, Subramani S, et al. Society of Cardiovascular Anesthesiologists Clinical Practice Improvement Advisory for Management of Perioperative Bleeding and Hemostasis in Cardiac Surgery Patients. Anesth Analg. 2019;129:1209-1221.

Boer C, Meesters MI, Milan Milojevic M, et al.;Task Force on Patient Blood Management for Adult Cardiac Surgery of the European Association for Cardio-Thoracic Surgery (EACTS) and the European Association of Cardiothoracic Anaesthesiology (EACTA); 2017 EACTS/EACTA Guidelines on patient blood management for adult cardiac surgery.
J Cardiothorac Vasc Anesth. 2018;32:88-120.

American Society of Anesthesiologists Task Force on Perioperative Blood Management. Practice Guidelines for Perioperative Blood Management: An Updated Report by the American Society of Anesthesiologists Task Force on Perioperative Blood Management. Anesthesiology. 2015;122:241-75.

Trauma

Rossaint R, Afshari A, Bouillon B, et al. The European guideline on management of major bleeding and coagulopathy following trauma: sixth edition. Crit Care. 2023;27:80.

American College of Surgeons Committee on Trauma (2014). ACS TQIP Massive Transfusion in Trauma Guidelines.

Upon arrival in the ICU, baseline laboratory measures should be obtained and then repeated as needed or at least hourly: INR, aPTT, fibrinogen level, hemoglobin or hematocrit, platelet count, viscoelastic point-of-care testing (if available), ionized calcium, blood gas testing (including base deficit).
Once laboratory data are available, resuscitation should be goal directed based on the laboratory findings and clinical evidence of ongoing bleeding.

Liver Transplantation

Brustia R, Monsel A, Skurzak S, et al. Guidelines for Perioperative Care for Liver Transplantation: Enhanced Recovery After Surgery (ERAS) Recommendations. Transplantation. 2022;106:552-561.

Yoon U, Bartoszko J, Bezinover D, et al.; ERAS4OLT.org Working Group. Intraoperative transfusion management, antifibrinolytic therapy, coagulation monitoring and the impact on short-term outcomes after liver transplantation-A systematic review of the literature and expert panel recommendations. Clin Transplant. 2022;36:e14637.